Associations between Indoor CO2 Concentrations and Sick Building Syndrome Symptoms in US Office Buildings: An Analysis of the 1994-1996 BASE Study Data

TitleAssociations between Indoor CO2 Concentrations and Sick Building Syndrome Symptoms in US Office Buildings: An Analysis of the 1994-1996 BASE Study Data
Publication TypeJournal Article
Year of Publication2000
AuthorsMichael G Apte, William J Fisk, Joan M Daisey
JournalIndoor Air
Volume10
Issue4
Pagination246-257
Date Published07/2000
Keywordscarbon dioxide, Dose-response, multivariate logistic regression, office workers, sick building syndrome, vntilation
Abstract

Higher indoor concentrations of air pollutants due, in part, to lower ventilation rates are a potential cause of sick building syndrome (SBS) symptoms in office workers. The indoor carbon dioxide (CO2) concentration is an approximate surrogate for indoor concentrations of other occupant-generated pollutants and for ventilation rate per occupant. Using multivariate logistic regression (MLR) analyses, we evaluated the relationship between indoor CO2 concentrations and SBS symptoms in occupants from a probability sample of 41 U.S. office buildings. Two CO2 metrics were constructed: average workday indoor minus average outdoor CO2 (dCO2, range 6-418 ppm), and maximum indoor one-hour moving average CO2 minus outdoor CO2 concentrations (dCO2MAX). MLR analyses quantified dCO2/SBS symptom associations, adjusting for personal and environmental factors. A dose-response relationship (p<0.05) with odds ratios per 100 ppm dCO2 ranging from 1.2 to 1.5 for sore throat, nose/sinus, tight chest, and wheezing was observed. The dCO2MAX/SBS regression results were similar. Implications: large increases in ventilation rate or improvements in ventilation effectiveness and/or indoor pollutant source control would be expected to decrease the prevalence of selected symptoms by up to 70-85%.

DOI10.1034/j.1600-0668.2000.010004246.x
LBNL Report Number

LBNL-44385